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Donny Osmond has personally experienced the health-promoting benefits of Protandim, The Nrf2 Synergizer.

“I feel compelled to share it,” Osmond said. “Whenever I have the opportunity to discuss health and wellness, I mention Protandim because it has made a difference in my life.”

Osmond’s doctor was at first skeptical about a supplement and its claims to reduce oxidative stress an average of 40 percent in 30 days. The doctor wanted to study it for himself and perform his own tests to determine its validity and effectiveness. His testing verified Protandim, and his perception changed from skepticism to advocacy. He recommended Donny incorporate Protandim into his health routine and to make it a part of his daily health regimen.

“I talk a lot about good health because it’s a priority for me; I believe in staying fit and getting regular exercise,” Donny said. “Throughout my life, I’ve been on the lookout for products that help me maintain my youth and vigor. I’ve done my research and it led me to Protandim. I love Protandim, I take it every day!”

Side effects

The side effects of Protandim may include allergic responses, gastrointestinal disturbances (stomach ache, diarrhea, vomiting), headache, and rash of the hands and feet.

Human clinical studies
Two studies of Protandim have been conducted in human subjects. One of these studies, a non-randomized, non-controlled trial, reported that Protandim increased the levels of the antioxidant enzymes SOD and catalase while reducing TBAR levels.[7][21]
The second study, a double-blinded, randomized, placebo-controlled trial published by McCord and colleagues in 2012, examined the effect of Protandim on pulmonary oxidative stress and alveolar epithelial permeability in 30 recovering alcoholics.[22] Protandim (14 subjects at a dose of 1350 mg/day; double the daily dose recommended by the manufacturer) or placebo (in 16 subjects) were administered for 7 days. Relative to placebo-treatment, Protandim had no significant effects on alveolar epithelial permeability or on oxidative stress, epithelial growth factor, fibroblast growth factor, interleukin-1β, and interleukin-10 levels in bronchoalveolar lavage fluid. Treatment with placebo, however, produced a significant reduction in plasma levels of TBARS, a marker of oxidative stress (i.e., lipid peroxidation).