Ivermectin dosage, cutting through the misinformation

[Gunnar]

I don’t have a problem with anyone taking Invermectin as prescribed by credible physicians, in legitimate settings, where they take their patients’ vitals, weight, and screen their medical history. I’m taking vitamin D after having talked to my doctor - she mentioned that it could be helpful as another tool in my body’s defense against Covid in case I get infected. So I take it daily now. But, yeah, I agree with your hot take. People, from what I see, have no tolerance for common ground if it makes ‘the other side’ not look as bad.

- Doc

I agree that this is a very reasonable stance. It is stupid to oppose something that works, or may work, just because "it makes 'the other side' not look as bad." As I am sure you agree, the potential danger is in the attitude many ivermectiin advocates seem to have that they don't need to be vaccinated, as long as Ivermectin is available to treat and mitigate the symptoms of covid-19, should they happen to get it. Given the preponderance of the evidence, the vaccines do work and are safe, even if they are not 100% effective. Why is preventing one from getting the disease in the first place not wiser than merely counting on treating it with some medication that may or may not save you from serious illness or death, should you happen to get it?

[Alf'Omega]

I don’t have a problem with anyone taking Invermectin as prescribed by credible physicians, in legitimate settings, where they take their patients’ vitals, weight, and screen their medical history. I’m taking vitamin D after having talked to my doctor - she mentioned that it could be helpful as another tool in my body’s defense against Covid in case I get infected. So I take it daily now. But, yeah, I agree with your hot take. People, from what I see, have no tolerance for common ground if it makes ‘the other side’ not look as bad.

- Doc

I agree that this is a very reasonable stance. It is stupid to oppose something that works, or may work, just because "it makes 'the other side' not look as bad." As I am sure you agree, the potential danger is in the attitude many ivermectiin advocates seem to have that they don't need to be vaccinated, as long as Ivermectin is available to treat and mitigate the symptoms of covid-19, should they happen to get it. Given the preponderance of the evidence, the vaccines do work and are safe, even if they are not 100% effective. Why is preventing one from getting the disease in the first place not wiser than merely counting on treating it with some medication that may or may not save you from serious illness or death, should you happen to get it?

The thing is, there is no evidence it "works" to treat COVID. The Right has been fabricating fake cures since the beginning, as a way to stick it to the Left because they've been hilariously wrong since their leader said to inject disinfectants into our blood. If it already has a cure, then there is no reason to vaccinate yourself with Bill Gates microchips. This is how ridiculously stupid these damned people are and they deserve every bit of criticism that comes their way, especially when their actions are resulting in more needless deaths. They've politicized the living hell out of COVID, masks, vaccines, and now this dumb crap. They're trying to use the Left's response to another fake cure as a political tool.

[Gunnar]

The thing is, there is no evidence it "works" to treat COVID. The Right has been fabricating fake cures since the beginning, as a way to stick it to the Left because they've been hilariously wrong since their leader said to inject disinfectants into our blood. If it already has a cure, then there is no reason to vaccinate yourself with Bill Gates microchips. This is how ridiculously stupid these damned people are and they deserve every bit of criticism that comes their way, especially when their actions are resulting in more needless deaths. They've politicized the living hell out of COVID, masks, vaccines, and now this dumb crap. They're trying to use the Left's response to another fake cure as a political tool.

I don't disagree with any of the above, especially the abject stupidity and self-serving dishonesty of how "They've politicized the living hell out of COVID, masks, vaccines, and now this dumb crap. They're trying to use the Left's response to another fake cure as a political tool."

[Gunnar]

Fluvoxamine and COVID-19: Here’s How the OCD Drug Might Help Prevent COVID-19 Infections From Getting Worse

I posted this link here, because it also mentioned ivermectin and compared the two. It might have been more appropriate to post it in the vaccines and therapeutics thread.

The COVID-19 vaccine rollout has been the main focus of attention over the last few months—more than 90 million doses have been administered since distribution began on December 14, 2020 at a rate of more than 2.2 million shots per day. But at the same time, scientists have continued to work hard to find treatments for people who get infected.

One of them, the generic drug fluvoxamine, has shown huge potential. Developed 40 years ago as an antidepressant, fluvoxamine—sometimes known as Luvox—has been used mainly to treat obsessive-compulsive disorder (OCD), per the National Alliance on Mental Illness (NAMI). But now, researchers are taking a closer look at how the medication could be an important treatment to prevent patients who test positive for COVID-19 from getting seriously ill with the infection.

In a new interview with 60 Minutes, Angela Reiersen, MD, a child psychiatrist at Washington University in St. Louis—and co-author of a November 2020 study published in the Journal of the American Medical Association (JAMA) regarding the use of fluvoxamine in COVID-19 patients—explained that she first got the idea that the drug could potentially treat COVID-19 after seeing research that fluvoxamine prevented sepsis in mice.

"I thought, well, I wonder if we could use fluvoxamine to treat COVID and prevent that clinical deterioration," Dr. Reiersen told 60 Minutes.

Dr. Reiersen and her colleagues—including Eric Lenze, MD, a fellow psychiatrist at Washington University who also specializes in finding new uses for drugs that are already approved by the Food and Drug Administration (FDA)—went on to conduct the small randomized clinical trial on fluvoxamine and COVID-19 patients.

The results of that JAMA study found that participants with symptomatic COVID-19 who were treated with fluvoxamine "had a lower likelihood of clinical deterioriation" than those who were given a placebo. "The results were really pretty incredible," Dr. Lenze told Alfonsi. "Out of the 80 people who received fluvoxamine, none, zero of them deteriorated versus 8% of the people who got [the] placebo."

. . .

Fluvoxamine vs Other Options

The recommendations below are based on both scientific studies and the experience of clinicians in treating COVID-19.

There are many drugs and supplements that have varying levels of positive effectiveness against the virus including inhaled budesonide, bromhexine, vitamin D, and HCQ. All of these have the greatest value when started as early as possible. There is no benefit to waiting. In general, these drugs (and supplements) are safe with very low side-effect profiles. Your doctor may recommend adding one or more of these drugs at the start of treatment in addition to ivermectin and fluvoxamine. For patients with severe or worsening respiratory symptoms, 4-8 mg cyproheptadine 3-4 times a day has been shown to be very helpful as well.

The combination of ivermectin and fluvoxamine is extremely effective when used ASAP. Two of the most effective drugs to treat Covid early are ivermectin and fluvoxamine. Both drugs should be started together at the same time. If you are treated within 48 hours of first symptoms, research shows that ivermectin should be given at a dose of 0.4mg/kg for a minimum of 5 days or until symptoms resolve, whichever is later. Fluvoxamine should be given as 50 mg twice a day for 14 days. The website www.c19early.com shows that these are the two approved drugs which individually have shown to be the most effective against Covid in two or more studies. Used together, these drugs have no common adverse interactions and have complementary mechanisms of action. For instance, fluvoxamine is a potent anti-inflammatory and, because it is able to penetrate the blood-brain barrier, it is effective in preventing inflammation in your brain. Unlike systemic steroids, fluvoxamine does not impair your ability to fight the virus so it can be used immediately. The fluvoxamine dose effective against Covid is just one third of the FDA-approved dose so side effects are very rare and minimal. I am not aware of anyone who started both drugs within 48 hours of first symptoms who didn’t have a rapid recovery. The best method to catch the virus early is to test regularly, and start treatment upon a positive test. This is because the PCR test can detect Covid before symptoms start.

If fluvoxamine isn’t available, fluoxetine is a viable substitute (Scientific Reports 2021). All the data we’ve seen shows that if you can’t get fluvoxamine, using 30mg once a day of fluoxetine (Prozac) is equally effective (equivalent to 50mg twice a day of fluvoxamine).

Fluvoxamine is in top position as a treatment against COVID-19 >

My emphasis added.

[Alf'Omega]

What's the source? The link doesn't work.

[Gunnar]

What's the source? The link doesn't work.

Sorry about that. Try it again, I fixed the link.

[Res Ipsa]

Gunnar,

I think the source of that article may warrant some looking into. The FLCCC looks a little sketchy. https://www.google.com/amp/s/www.the-sc ... -68505/amp

[Atlanticmike]

Gunnar,

I think the source of that article may warrant some looking into. The FLCCC looks a little sketchy. https://www.google.com/amp/s/www.the-sc ... -68505/amp

Ivermectin had been prescribed by doctors forever. Gee whiz!! You guys are ridiculous. Get over your cult think.

[Res Ipsa]

Gunnar,

I think the source of that article may warrant some looking into. The FLCCC looks a little sketchy. https://www.google.com/amp/s/www.the-sc ... -68505/amp

Ivermectin had been prescribed by doctors forever. Gee whiz!! You guys are ridiculous. Get over your cult think.

Mike, I’m not talking about its on-label use. I’m talking about whether the evidence shows it is effective against COVID-19 and whether the source that Gunnar linked to is credible.

https://sciencebasedmedicine.org/iverme ... ne-take-2/

The FLCCC is an advocacy group that pushes their own protocol for treatment of COVID-19. They routinely misrepresent the scientific literature on the subjects. That’s not to say that Ivermectin has been ruled out as an effective COVID-19 treatment. It does mean one should take some time to check other sources. Having a paper pulled for misrepresenting the evidence and failure to disclose conflicts of interest is a big deal.

[Atlanticmike]

Ivermectin had been prescribed by doctors forever. Gee whiz!! You guys are ridiculous. Get over your cult think.

Mike, I’m not talking about its on-label use. I’m talking about whether the evidence shows it is effective against COVID-19 and whether the source that Gunnar linked to is credible.

https://sciencebasedmedicine.org/iverme ... ne-take-2/

The FLCCC is an advocacy group that pushes their own protocol for treatment of COVID-19. They routinely misrepresent the scientific literature on the subjects. That’s not to say that Ivermectin has been ruled out as an effective COVID-19 treatment. It does mean one should take some time to check other sources. Having a paper pulled for misrepresenting the evidence and failure to disclose conflicts of interest is a big deal.

The real question is, what are you doing up this early ?